Published: 27 December, 2023 | Volume 6 - Issue 1 | Pages: 001-004
Figure 1:
Figure 1: Mannose metabolic pathway and main steps in the GPI anchor biosynthesis featuring mannose residues. For 2 types of CDG syndrome, mannose phosphate isomerase- (MPI) and phosphomannomutase 2 (PMM2) deficiency, mannose can bypass the enzymatic defect and contribute to the GDP-mannose pool. In the further biosynthetic pathway of GPI Dol-P-Man is transferred by the mannosyltransferases I-III (PIGM, PIGV and PIGB) to build the common core of the GPI-anchor.
Read Full Article HTML DOI: 10.29328/journal.jgmgt.1001008 Cite this Article Read Full Article PDF
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