Figure 1

The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy

Jacques P Tremblay* and Jean-Paul Iyombe-Engembe

Published: 25 July, 2017 | Volume 1 - Issue 1 | Pages: 019-036

jgmgt-aid1003-g001

Figure 1:

Diagram of transplantation of allogeneic myoblasts by intramuscular route. a) Injection of allogeneic myoblasts into the patient's muscle with a needle. b) The injected myoblasts migrate to the perimysium space due to the chemotactic gradient. c) The regeneration of part of the patient muscle fiber (blue). d) Muscle regeneration occurs in the necrotic part of the patient's muscle fiber. e) The regenerated part of the muscle fiber express proteins coded by the exogenous nuclei. f) The transplanted myoblasts also form new satellite cells. g) The grafted myoblasts can fuse together. h) This results in the formation of new muscle fibers.

Read Full Article HTML DOI: 10.29328/journal.jgmgt.1001003 Cite this Article Read Full Article PDF

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